Yes, patients may be able to switch from Mounjaro to the Wegovy pill, but this is not a direct like-for-like dose conversion.
Mounjaro contains tirzepatide, which works on both GIP and GLP-1 receptors. Wegovy contains semaglutide, which is a GLP-1 receptor agonist. Because they are different medicines, the doses cannot be matched exactly.
Mounjaro to Wegovy pill switching guide
If you are currently using Mounjaro, the table below shows the estimated Wegovy pill dose that may be recommended based on your current Mounjaro dose.
| Current Mounjaro dose | Recommended Wegovy pill dose |
|---|---|
| 2.5mg weekly | 1.5mg once daily |
| 5mg weekly | 4mg once daily |
| 7.5mg weekly | 9mg once daily |
| 10mg weekly | 9mg once daily |
| 12.5mg weekly | 25mg once daily |
| 15mg weekly | 25mg once daily |
This switching guide is based on clinical judgement and extrapolated dose comparisons. Switching from Mounjaro to the Wegovy pill is considered off-label, meaning it has not been formally evaluated in clinical trials.
However, real-world data and clinical experience when switching between GLP-1 medicines suggest that many patients tolerate the transition well, with side effects generally limited to those commonly seen with GLP-1 treatments, such as nausea, constipation, diarrhoea, reflux, or reduced appetite.
You should not use Mounjaro and Wegovy together. Your prescriber will advise when to stop Mounjaro and when to start Wegovy tablets, based on your current dose, side effects, treatment history, and weight loss progress.
If you are a new customer then you can complete our online consultation form which will guide you through the switching process, and if you are an existing customer you can log in to your Lotus account and click 'Re-order' and then choose to change your medication.