Yes. Some patients may be able to switch from a Wegovy injection to Foundayo or from Foundayo to a Wegovy injection following a prescriber review. The medicines are not directly interchangeable, and the dose offered will depend on your current treatment, when you last used it, how long you have taken it and whether you have experienced any side effects.
Wegovy contains semaglutide and is injected once weekly. Foundayo contains orforglipron and is taken as a tablet once daily.
Switching from a Wegovy injection to Foundayo
| Current Wegovy injection dose | Estimated Foundayo switching dose |
|---|---|
| 0.25 mg once weekly | 0.8 mg once daily |
| 0.5 mg once weekly | 2.5 mg once daily |
| 1 mg once weekly | 5.5 mg once daily |
| 1.7 mg once weekly | 9 mg once daily |
| 2.4 mg once weekly | 9 mg once daily |
| 7.2 mg once weekly | 9 mg once daily |
Switching from Foundayo to a Wegovy injection
| Current Foundayo dose | Estimated Wegovy injection switching dose |
| 0.8 mg once daily | 0.25 mg once weekly |
| 2.5 mg once daily | 0.5 mg once weekly |
| 5.5 mg once daily | 1 mg once weekly |
| 9 mg once daily | 1.7 mg once weekly |
| 14.5 mg once daily | 1.7 mg once weekly |
| 17.2 mg once daily | 1.7 mg once weekly |
These tables are Lotus’s estimated switching guidance. There is no clinically proven dose-for-dose conversion between semaglutide injections and Foundayo. Starting Foundayo above its usual 0.8 mg starting dose, or starting a Wegovy injection above its usual 0.25 mg starting dose, is an off-label switching approach that has not been formally evaluated in a direct clinical trial.
Your prescriber will confirm your starting dose after reviewing your current treatment, when you last took it, how well you have tolerated it and whether you have experienced any side effects. A lower dose may be recommended if you have had side effects or a break in treatment.
Wegovy and Foundayo must not be taken together. Your prescriber will tell you when to take your final dose of your current medication and when to begin the new one.
New customers can complete our online consultation. Existing Lotus customers can log in to their account, select Re-order and choose the option to change medication.