Yes. Some patients may be able to switch from Mounjaro to Foundayo or from Foundayo to Mounjaro following a clinical assessment. However, these medicines are not directly interchangeable and there is no exact dose-for-dose conversion between them.
Mounjaro contains tirzepatide and acts on both GIP and GLP-1 receptors. It is given as an injection once weekly. Foundayo contains orforglipron, acts on the GLP-1 receptor and is taken as a tablet once daily.
Switching from Mounjaro to Foundayo
| Current Mounjaro dose | Estimated Foundayo switching dose |
| 2.5 mg once weekly | 0.8 mg once daily |
| 5 mg once weekly | 2.5 mg once daily |
| 7.5 mg once weekly | 5.5 mg once daily |
| 10 mg once weekly | 9 mg once daily |
| 12.5 mg once weekly | 9 mg once daily |
| 15 mg once weekly | 9 mg once daily |
Switching from Foundayo to Mounjaro
Patients switching to Mounjaro will usually begin with its standard starting dose of 2.5 mg once weekly, regardless of their current Foundayo dose.
| Current Foundayo dose | Suggested Mounjaro starting dose |
| 0.8 mg once daily | 2.5 mg once weekly |
| 2.5 mg once daily | 2.5 mg once weekly |
| 5.5 mg once daily | 2.5 mg once weekly |
| 9 mg once daily | 2.5 mg once weekly |
| 14.5 mg once daily | 2.5 mg once weekly |
| 17.2 mg once daily | 2.5 mg once weekly |
These tables are Lotus’s estimated switching guidance. There is no clinically proven dose-for-dose conversion between Mounjaro and Foundayo. Starting Foundayo above its usual 0.8 mg starting dose is an off-label switching approach that has not been formally evaluated in a direct clinical trial.
Your prescriber will confirm your starting dose after reviewing your current treatment, when you last took it, how well you have tolerated it and whether you have experienced any side effects. A lower dose may be recommended if you have had side effects or a break in treatment.
Mounjaro and Foundayo must not be taken together. Your prescriber will tell you when to stop your current medication and when to begin the new one.
New customers can complete our online consultation. Existing Lotus customers can log in to their account, select Re-order and choose the option to change medication.